Alstoscholarisine M, a 6,7-seco-vallesamine monoterpenoid indole alkaloid with antimicrobial activity from Alstonia scholaris
Abstract Alstoscholarisine M is a 6,7-seco-vallesamine monoterpenoid indole alkaloid with a rarely methylcarbamate fragment, isolated from the leaves of Alstonia scholaris. Extensive spectroscopic data analyses, quantum chemical computations, and single-crystal X-ray diffraction elucidated its structure. The fascinating compound exhibited potential antifungal activity against Trichophyton rubrum, and its activity was roughly comparable to the first-line antifungal drug griseofulvin and significantly more effective than berberine, an important antimicrobial drug originated from plants. Supplementary files Article information DOI https://doi.org/10.1039/D5OB00420A Article type Paper Submitted 09 Mar 2025 Accepted 27 Mar 2025 First published 02 Apr 2025 Download Citation Org. Biomol. Chem., 2025, Accepted Manuscript Permissions Alstoscholarisine M, a 6,7-seco-vallesamine monoterpenoid indole alkaloid with antimicrobial activity from Alstonia scholaris H. F. Yu, L. C. Zhang, K. Mohamed, L. Li, J. Yao, Y. Liu, X. Li, C. Ding, R. Zhang and X. Luo, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00420A To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given. If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page. Read more about how to correctly acknowledge RSC content. Social activity Spotlight Advertisements