CMCS/PEGDA-based photoresponsive hydrogel with high efficiency for gingival retraction and rapid hemostasis
Abstract Prosthodontics is a dental specialty with a long history of providing patients with prostheses to restore or replace damaged or missing teeth and dentition. Gingival retraction is a vital step after tooth preparation to obtain aesthetic and functional restorations. Gingival retraction materials have been used in clinics and are among the most prospective alternatives to gingival retraction cords. However, gingival bleeding, increased tension of the gingiva, and saliva flushing after tooth preparation might cause difficulties in gingival retraction. The previous materials generally have inadequate mechanical strength, poor hemostasis, and irritating effects. To achieve effective and rapid gingival retraction and hemostasis is a key clinical challenge. This article has described a novel photoresponsive hydrogel based on carboxymethyl chitosan/polyethylene glycol diacrylate (CMCS/PEGDA). CMCS/PEGDA hydrogel injected into the gingival sulcus can rapidly solidify and absorb blood, concentrate clotting factors, and expand to push away the gingiva under blue light illumination. At the same time, CMCS/PEGDA hydrogel has excellent rheological properties, mechanical strength, and potent water absorption capacity. Additionally, CMCS/PEGDA hydrogel can aggregate blood cells and promote clotting. The novel composite hydrogel developed in this study has distinguished biocompatibility, splendid mechanical properties, and wonderful hemostasis ability, demonstrating the potential for application in the field of gingival retraction. Supplementary files Article information DOI https://doi.org/10.1039/D5TB00755K Article type Paper Submitted 01 Apr 2025 Accepted 01 Jul 2025 First published 03 Jul 2025 Download Citation J. Mater. Chem. B, 2025, Accepted Manuscript Permissions CMCS/PEGDA-based photoresponsive hydrogel with high efficiency for gingival retraction and rapid hemostasis J. Wu, Y. Liang, R. Li, M. Qiao, X. Pei, X. Yuan, Q. Wan and J. Wang, J. Mater. Chem. B, 2025, Accepted Manuscript , DOI: 10.1039/D5TB00755K To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given. If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page. Read more about how to correctly acknowledge RSC content. Social activity Spotlight Advertisements